| Name | Profession | Movie or TV appearance | Has Smoked IRL (In Real Life) | Quit |
| Ioana Iacob | actress | Yes | ||
| Janis Ian | musician | ?Yes? | ||
| Mirta Ibarra | actress | Yes | ||
| Sarimah Ibrahim | actress | Yes | ||
| Lillebil Ibsen | actress | Yes | ||
| Patricia Idlette | actress | Yes | ||
| Iman | actress/model | Yes | Yes? | Yes? |
| Natalie Imbruglia | actress | Yes? | Yes? | |
| Deirdre Imershein | actress | Yes | ||
| Rebecca Immanuel | actress | Yes | ||
| Celia Imrie | actress | Yes | ||
| Francesca Inaudi | actress | Yes | ||
| Annabella Incontrera | actress | Yes | ||
| Mariah Inger | actress | Yes | Yes | |
| Randi Ingerman | actress | Yes | ? | |
| Elisa Ingram | actress | Yes | ||
| Frankie Ingrassia | actress | Yes | ||
| Alessia Innocenti | actress | Yes | ||
| Kathy Ireland | actress | Yes | ||
| Cristen Irene | actress | Yes | ||
| Elena Irureta | actress | Yes | ||
| Amy Irving | actress | Yes | Yes? | |
| Hollis Irving | actress | Yes | ||
| Jennifer Irwin | actress | Yes | ||
| Katharine Isabelle | actress | Yes | Yes? | |
| Kate Isitt | actress | Yes | ||
| Nancy Ison | actress | Yes | ||
| Maya Israel | actress | Yes | ||
| Giselle Itié | actress | ?Yes? | ||
| Kiyomi Ito | actress | Yes | ||
| Stephanie Ittleson | actress | Yes | ||
| Nina Ivanisin | actress | Yes | ||
| Terri Ivens | actress | Yes | ||
| Judith Ivey | actress | Yes | ||
| Dana Ivgy | actress | Yes | ||
| Eleonora Ivone | actress | Yes | ||
| Kalpana Iyer | actress | Yes |